Quantitative Assessment of Lung Microstructure in Healthy Mice using Lung Morphometry with Hyperpolarized 3He Diffusion MRI
نویسندگان
چکیده
E. Osmanagic, A. L. Sukstanskii, J. D. Quirk, J. C. Woods, M. S. Conradi, and D. A. Yablonskiy Electrical and Systems Engineering, Washington University, St. Louis, Misssouri, United States, Radiology, Washington University, St. Louis, Missouri, United States, Radiology, Washington University, St. Louis, Misssouri, United States, Physics, Washington University, St. Louis, Missouri, United States, Physics, Washington University, St. Louis, Misssouri, United States
منابع مشابه
Imaging lung microstructure in mice with hyperpolarized 3He diffusion MRI.
Quantitative measurement of lung microstructure is of great significance in assessment of pulmonary disease, particularly in the earliest stages. The technique for MRI-based 3He lung morphometry was previously developed and validated for human lungs, and was recently extended to ex vivo mouse lungs. The technique yields accurate, quantitative information about the microstructure and geometry of...
متن کاملIn vivo lung morphometry with hyperpolarized 3He diffusion MRI in canines with induced emphysema: disease progression and comparison with computed tomography.
Despite a long history of development, diagnostic tools for in vivo regional assessment of lungs in patients with pulmonary emphysema are not yet readily available. Recently, a new imaging technique, in vivo lung morphometry, was introduced by our group. This technique is based on MRI measurements of diffusion of hyperpolarized (3)He gas in lung air spaces and provides quantitative in vivo tomo...
متن کاملQuantitative in vivo assessment of lung microstructure at the alveolar level with hyperpolarized 3He diffusion MRI.
The study of lung emphysema dates back to the beginning of the 17th century. Nevertheless, a number of important questions remain unanswered because a quantitative localized characterization of emphysema requires knowledge of lung structure at the alveolar level in the intact living lung. This information is not available from traditional imaging modalities and pulmonary function tests. Herein,...
متن کاملQuantitative assessment of lung microstructure in healthy mice using an MR-based 3He lung morphometry technique.
The recently developed technique of lung morphometry using hyperpolarized (3)He diffusion magnetic resonance (MR) (Yablonskiy DA, Sukstanskii AL, Woods JC, Gierada DS, Quirk JD, Hogg JC, Cooper JD, Conradi MS. J Appl Physiol 107: 1258-1265, 2009) permits in vivo study of lung microstructure at the alveolar level. Originally proposed for human lungs, it also has the potential to study small anim...
متن کاملHIGHLIGHTED TOPIC Physiological Imaging of the Lung In vivo lung morphometry with hyperpolarized He diffusion MRI in canines with induced emphysema: disease progression and comparison with computed tomography
Tanoli TSK, Woods JC, Conradi MS, Bae KT, Gierada DS, Hogg JC, Cooper JD, Yablonskiy DA. In vivo lung morphometry with hyperpolarized He diffusion MRI in canines with induced emphysema: disease progression and comparison with computed tomography. J Appl Physiol 102: 477–484, 2007. First published July 27, 2006; doi:10.1152/japplphysiol.00397.2006.—Despite a long history of development, diagnost...
متن کامل